Triazole phenotypes and genotypic characterization of clinical Aspergillus fumigatus isolates in China
                    
                        
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                    چکیده
منابع مشابه
Triazole Resistance in Aspergillus fumigatus Clinical Isolates Obtained in Nanjing, China
BACKGROUND During the past decades, the incidence of invasive aspergillosis (IA) caused by Aspergillus fumigatus has increased dramatically. The aims of this study were to investigate the susceptibility of clinical isolates of A. fumigatus to triazole and the underlying cyp51A mutations in triazole-resistant A. fumigatus. METHODS A total of 126 A. fumigatus clinical isolates from 126 patients...
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Twenty-three sequential Aspergillus fumigatus sputum isolates, which had been collected over a period of 2 years, from two patients with cystic fibrosis were genotyped by random amplified polymorphic DNA PCR and restriction fragment length polymorphism analysis. In patient B, one genotype was predominantly present in the sputum samples, while in the other patient up to nine different genotypes ...
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To determine if cases of invasive aspergillosis (IA) were caused by strains of Aspergillus fumigatus with unique characteristics, strains from immunosuppressed patients with IA were compared to strains obtained from sputa of patients with cystic fibrosis and to strains from the environment. An extremely high genomic diversity was observed among the 879 strains typed by Southern blotting with a ...
متن کاملComparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients
Citation: Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath P-M, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann W-K, Buchheidt D and Spiess B (2018) Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients. Front. M...
متن کاملEvaluation of performance of four genotypic methods for studying the genetic epidemiology of Aspergillus fumigatus isolates.
In the present investigation, 49 Aspergillus fumigatus isolates obtained from four nosocomial outbreaks were typed by Afut1 restriction fragment length polymorphism (RFLP) analysis and three PCR-based molecular typing methods: random amplified polymorphic DNA (RAPD) analysis, sequence-specific DNA primer (SSDP) analysis, and polymorphic microsatellite markers (PMM) analysis. The typing methods ...
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ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2017
ISSN: 2222-1751
DOI: 10.1038/emi.2017.97