Triazole phenotypes and genotypic characterization of clinical Aspergillus fumigatus isolates in China

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Triazole Resistance in Aspergillus fumigatus Clinical Isolates Obtained in Nanjing, China

BACKGROUND During the past decades, the incidence of invasive aspergillosis (IA) caused by Aspergillus fumigatus has increased dramatically. The aims of this study were to investigate the susceptibility of clinical isolates of A. fumigatus to triazole and the underlying cyp51A mutations in triazole-resistant A. fumigatus. METHODS A total of 126 A. fumigatus clinical isolates from 126 patients...

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Genetic diversity among clinical and environmental isolates of Aspergillus fumigatus.

To determine if cases of invasive aspergillosis (IA) were caused by strains of Aspergillus fumigatus with unique characteristics, strains from immunosuppressed patients with IA were compared to strains obtained from sputa of patients with cystic fibrosis and to strains from the environment. An extremely high genomic diversity was observed among the 879 strains typed by Southern blotting with a ...

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Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients

Citation: Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath P-M, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann W-K, Buchheidt D and Spiess B (2018) Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients. Front. M...

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ژورنال

عنوان ژورنال: Emerging Microbes & Infections

سال: 2017

ISSN: 2222-1751

DOI: 10.1038/emi.2017.97